Yeztugo

New HIV Prevention Drug Approved, Promises Global Impact

The FDA has approved lenacapavir, marketed as Yeztugo, a groundbreaking twice-yearly injection offering nearly complete protection against HIV. This capsid inhibitor, recognized as a major scientific breakthrough, has the potential to end the 44-year-long epidemic. To ensure global access, the manufacturer has entered royalty-free licensing agreements with generic drug producers and will supply the drug at no profit to countries in need, in partnership with the Global Fund. This preventative medication aims to transform HIV prevention by addressing adherence and stigma challenges associated with previous PrEP regimens.

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FDA Approves Twice-Yearly HIV Prevention Shot: Access, Not Science, Is the Challenge

The U.S. has approved lenacapavir (Yeztugo), a twice-yearly HIV prevention injection, marking a potential global breakthrough. Highly effective in clinical trials, reducing new infections nearly to zero in some groups, it offers a longer-lasting alternative to daily PrEP pills. However, access remains a concern due to U.S. healthcare funding cuts and global disparities, potentially limiting its impact despite Gilead’s efforts to provide low-cost versions in some countries. The high initial price also poses a challenge to widespread adoption.

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